Is there any evidence supporting potential neurotoxicity of Piracetam (racetams in general) and Modafinil combination?

I can't find source but I remember reading of potential risks of combining piracetam and modafinil. I was then very careful of doing so but tried anyway with great effect synergy. At least to me subjectively, this helps more than combining with aGPC (even though both affect ACh levels) Obviously it's not worth it if there's neurotoxicity potential down the road. I recall there being spike in piracetam studies in 2018 (which is interesting for such an old drug) so some of it might not be replicated yet. Is there potential of bad interaction between some racetams and modafinil? I'm interested in trying oxi/ani racetam as well and was wondering whether “clean” verdict for piracetam would generalize towards whole group. Read More

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